Impaired Baroreceptor Reflex Function of Older ASrAOGEN Rats
نویسندگان
چکیده
منابع مشابه
Baroreceptor reflex function.
THE IMPORTANCE of the baroreceptor reflex is to stabilize perfusion pressure in the face of disturbances of circulatory homeostasis. This is achieved by a number of neuronal (8, 29, 37, 48) and humoral (37, 45, 46) regulatory adjustments. These adjustments are initiated by a change in the pressure load at specialized pressure sensors located at the aortic arch and the carotid sinuses. Especiall...
متن کاملArterial baroreceptor reflex function in borderline hypertensive rats.
With increased dietary NaCl intake (8% NaCl), the borderline hypertensive rat develops hypertension, thus expressing the phenotype of the spontaneously hypertensive parent. Since arterial baroreceptor reflex function is impaired in the spontaneously hypertensive parent, it was the objective of this study to examine arterial baroreceptor reflex function in the borderline hypertensive rat made hy...
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BACKGROUND Impairment of the arterial baroreflex causes orthostatic hypotension. Arterial baroreceptor sensitivity degrades with age. Thus, an impaired baroreceptor plays a pivotal role in orthostatic hypotension in most elderly patients. There is no effective treatment for orthostatic hypotension. The aims of this investigation were to develop a bionic baroreceptor (BBR) and to verify whether ...
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Recent gene array and molecular studies have suggested that an abnormal gene expression profile of interleukin-6 (IL-6) in the nucleus tractus solitarii (NTS), a pivotal region for regulating arterial pressure, may be related to the development of neurogenic hypertension. However, the precise functional role of IL-6 in the NTS remains unknown. In the present study, we have tested whether IL-6 a...
متن کاملRelationship between baroreceptor reflex function and end-organ damage in spontaneously hypertensive rats.
The purpose of this study was to further illustrate the relationship between baroreceptor reflex sensitivity (BRS) and hypertensive end-organ damage (EOD) and to test the hypothesis that impairment of BRS aggravates EOD in hypertension. We studied baroreflex-mediated changes in heart rate [expressed as baroreceptor sensitivity to heart rate control (BRSHR)] and blood pressure [expressed as baro...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a1209